GB-115: A New Era in Anxiety and Cognitive Enhancement
GB-115
While the medical world takes decades to adopt new research, the evidence for a safer, more effective anxiolytic is already here. Dive deep into GB-115. Last Updated: June 16, 2025
Why Isn’t This a Global Standard?
“The medical community faces a significant lag… with pharmacological advancements taking an average of 21 years to integrate into practice… groundbreaking research findings can take up to 17 years to be fully incorporated.”
The case of GB-115 is a perfect illustration of this innovation gap. The data is compelling, backed by multiple phases of clinical trials. Yet, due to regulatory hurdles and a lack of widespread awareness, this therapeutic remains largely unknown outside of Russia and our small community.
A Uniquely Restorative Therapeutic
Pro-Cognitive
Enhances attention, reaction speed, and information processing, with benefits that build over time.[9]
Anti-Fatigue
Possesses activating properties that significantly combat mental fatigue and reduce daytime sleepiness.[10], [11]
Precise Pharmacology
The Wrong Turn: CCK2
Past research focused on CCK2 receptors, which modulate acute anxiety. This approach largely failed to produce effective long-term anxiolytics.[12]
Secondary Target: BRS3
Antagonism at BRS3 receptorsBombesin receptor subtype 3 (BRS3) is involved in regulating stress responses and energy balance. helps disinhibit GABAergic systemsGABA is the primary inhibitory neurotransmitter in the brain. Activating GABAergic systems produces calming effects. and reverse stress-related hyperactivity.[10]
Key Takeaways for Biohackers
Anxiety relief and cognitive enhancement are not mutually exclusive.
Targeting the right pathway (CCK1 for chronic anxiety) is a more effective long-term strategy.
A superior safety profile without tolerance or withdrawal is achievable in an anxiolytic.
The Clinical Journey
Compounding Cognitive Gains (Phase 2 Data)
Unlike typical anxiolytics, GB-115 progressively improved cognitive performance throughout the trial, suggesting a restorative neuroplastic effect.
Landmark Efficacy (Phase 3 Data)
The large-scale Phase 3 trial confirmed massive, statistically significant improvements over placebo.
Safety & Pharmacokinetics
Impeccable Safety
GB-115 demonstrates an exceptional safety level, a critical differentiator from existing treatments.
GB-115 VS Traditional Anxiety Medications
GB-115 was engineered to overcome the significant drawbacks of traditional anxiety medications. Here’s how it compares.
| Feature | GB-115 | Benzodiazepines |
|---|---|---|
| Cognitive Effects | Enhances cognition | Causes impairment[17] |
| Sedation & Fatigue | Activating; reduces fatigue | Causes drowsiness[18] |
| Abuse Potential | None observed | High risk[19] |
| Tolerance & Withdrawal | None observed[7] | Severe and dangerous[20] |
| Muscle Relaxation | No effect[10] | Common side effect[21] |
Feedback From the Community:
Advanced Biohacker
“This what it feels like to not have anxiety and be functional, very perquisite to adamant intimacy of joy without a burden to reconstructive pathological behavior of being dreaded through anxiousness or predisposition of incompetence of existential anxiety. Adding a threshold to my anxiety, being able to not have to worry about feeling inhibited by my unsteadily active mind. After using GB-115, I’m becoming an unwavering observer of my own self, I was noticing my mind was allowing the presence to flow through me and was becoming more aware of my mind and noticing that it’s predominantly at ease compared to my baseline state. I’m more so aware to what’s initially happening. Instead of always worried of what where to happen and going to happened or might happen. ”
Anxiety – 6mg intranasal administration
Biohacker #1
“The long standing advice of counting to 10 before giving a response or a reaction, well this is what GB-115 gives you without the counting. My response/reaction to any kind of news good or bad has been measured, calm and more mature. I am able to look at the news from a wider angle and don’t give up to my emotions. This has resulted in me being relaxed and have a measured response when facing uncertainty. I am at the age where I have started planning my post retirement finances. Until now it has been a up/down journey. I juggle between “This might not work (Panic!)” and “This might work”. Post GB-115, I am more confident and no longer think of the negative side. This has been replaced with a level of confidence that makes me think “This will work, I just need to sort few things” I am very happy with GB-115 and will definitely continue with it.”
Confidence and anxiety response – 15 days of 6mg intranasal administration.
Biohacker #2
“GB has made it easier for me to talk with strangers, no longer am I second or third guessing what I say, I’m no longer avoiding confrontation either. Has heightened my mood a lot, almost a manic feel at first but since leveled off, smiling a lot subconsciously and find it hard to stay upset. Now I will say it’s not a cure or even the most effective at improving social anxiety, it won’t make you super social but will make any social interaction that normally would feel tilted or awkward less so. I can talk to strangers like I know them and not as opponents that I dislike. However I say while it may be largely better for GAD vs social anxiety, it does still improve symptoms.”
Social anxiety and general mood – 1 week of 6mg intranasal administration
Biohacker #3
“I’ve noticed a significant drop in my overall stress levels. Unfortunately, I am a very anxious person. I’ve been dealing with it for as long as I can remember. I experience pretty much constant rumination, intrusive thoughts, shakiness, feels of being overwhelmed, etc. I have noticed maximum benefit mostly while working. I have been serving at a restaurant for the past few months after relocating across the country due to my partner’s job. It’s a high stress environment full of uncouth customers and run by malignant management. I’ve never worked in a worse environment, and is unlike any other restaurant I’ve encountered. Anyway, I feel like I have a calm focus while serving as of late. I seem to be able to roll with the punches. My partner has even noticed how I’m less irritable and anxious. I have been experiencing a little insomnia, but that was going on prior to using GB-115. I have slept well the past two nights. I’ve seemed to be eating a little less. I even have had less anxiety about leaving the house, and have been going on long walks everyday.”
Stress level and anxiety – 1 week of 6mg intranasal administration
References
- Comorbidity of GAD and ADHD… ScienceDirect.
- Immunocorrecting properties… PubMed.
- Antinociceptive properties… PubMed.
- Anti-Inflammatory Effects… Springer.
- Preclinical safety investigation… PubMed.
- Antidepressant effects… PubMed.
- Absence of tolerance/withdrawal…
Key preclinical data showing no dependence potential. - Pharmacokinetics of GB-115… PubMed.
- Cognitive effects in GAD…
Human trial data showing cognitive enhancement over time. - Phase 2 Trial Data… MediaSphera.
- Phase 3 Clinical Trial…
The landmark Phase 3 study confirming efficacy and safety. - CCK1 receptor antagonism… PubMed.
- Cholecystokinin and anxiety… PMC.
- CCK1 antagonism prevents fear… PubMed.
- Effects on…rhesus monkeys. PubMed.
- Pharmacokinetics…oral admin. Pharmacokinetica.ru.
- Benzodiazepine-Related Cognitive Impairment… PMC.
- Benzodiazepines effects… Better Health Channel.
- Benzodiazepines (Fact Sheet)… DEA.gov.
- Benzodiazepine withdrawal management… SA Health.
- Benzodiazepines (Benzos): How They Work… Cleveland Clinic.
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